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Penicillium marneffei infection within an osteolytic lesion in an HIV-negative patient

Guang-nan Liu1, Juan-shu Huang2, Xiao-ning Zhong1

  • 1Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|March 25, 2014
PubMed

Insights

This study reports a rare case of disseminated Penicillium marneffei infection in an HIV-negative woman, presenting with osteolytic lesions. The findings highlight distinct clinical features compared to infections in HIV-positive individuals.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Penicillium marneffei is a thermally dimorphic fungus endemic to Southeast Asia.
  • It typically causes disseminated infections in individuals with Human Immunodeficiency Virus (HIV).
  • Infection in HIV-negative individuals is exceptionally rare.

Observation:

  • A 40-year-old HIV-negative woman presented with fever, lymphadenopathy, and rash.
  • Diagnosis confirmed disseminated Penicillium marneffei infection via sternum biopsy.
  • Bone scan revealed osteolytic lesions in the clavicle and sternum.

Findings:

  • The patient's presentation and osteolytic lesion development are detailed.
  • Clinical manifestations in this HIV-negative patient are compared to those in HIV-positive cases.
  • This case underscores the potential for P. marneffei to cause severe disease in non-immunocompromised individuals.

Implications:

  • This case expands the understanding of Penicillium marneffei epidemiology and clinical spectrum.
  • It emphasizes the need for considering P. marneffei in endemic areas, even in HIV-negative patients with unusual presentations.
  • Highlights potential differences in disease presentation and management strategies between HIV-positive and HIV-negative patients.
Keywords:
Osteolytic lesionPenicilliosis marneffeiPenicillium marneffei

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