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Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder
Published on: November 25, 2025
Family-based exposure and response prevention therapy for preschool-aged children with obsessive-compulsive disorder:
Adam B Lewin1, Jennifer M Park2, Anna M Jones2
1Department of Pediatrics, University of South Florida, USA; Department of Psychology, University of South Florida, USA; Department of Psychiatry & Behavioral Neurosciences, University of South Florida, USA.
Insights
Family-based exposure/response prevention therapy (E/RP) significantly reduced obsessive-compulsive disorder (OCD) symptoms in very young children. This developmentally tailored E/RP approach was well-tolerated and effective, showing lasting results.
Area of Science:
- Child and Adolescent Psychiatry
- Behavioral Therapy
- Pediatric Mental Health
Background:
- Early-onset obsessive-compulsive disorder (OCD) in very young children presents unique treatment challenges.
- Limited research exists on the efficacy of specific therapies for this age group.
Purpose of the Study:
- To assess the feasibility, acceptability, and preliminary efficacy of family-based exposure/response prevention therapy (E/RP).
- To compare E/RP with treatment as usual (TAU) in children aged 3-8 years with early-onset OCD.
Main Methods:
- A randomized controlled trial involving 31 children (mean age 5.8 years) diagnosed with OCD.
- Participants were assigned to either family-based E/RP (12 sessions over 6 weeks) or TAU.
- Outcomes were measured using the Children's Yale-Brown Obsessive Compulsive Scale and Clinical Global Impression at baseline, post-treatment, and 1- and 3-month follow-ups.
Main Results:
- A significant group effect favored E/RP over TAU (d = 1.69).
- Treatment responders were 65% in the E/RP group versus 7% in the TAU group.
- Symptom remission was achieved by 35.2% of the E/RP group, with no remission in the TAU group. Gains were maintained at 3 months.
Conclusions:
- Developmentally tailored E/RP is effective and well-tolerated for reducing OCD symptoms in children as young as 3 years.
- Key adaptations include extensive parent involvement, addressing family accommodation, and frequent sessions.
- Family-based E/RP offers a promising treatment for early-onset pediatric OCD.
Aims:
To examine the feasibility, acceptability and preliminary efficacy of family-based exposure/response prevention therapy (E/RP) versus treatment as usual (TAU) in a cohort of very young children with early onset obsessive-compulsive disorder (OCD).
Methods:
Thirty-one children ages 3-8 years (M = 5.8 years) with a primary diagnosis of OCD were randomized to E/RP or TAU. The E/RP condition received 12 sessions of family-based E/RP twice weekly over 6 weeks. Families were assessed at baseline, post-treatment, 1-month and 3-month follow up. The Children's Yale Brown Obsessive Compulsive Scale and Clinical Global Impression served as primary outcome measures.
Results:
A large group effect emerged in favor of the E/RP group (d = 1.69). Sixty-five percent of the E/RP group was considered treatment responders as compared to 7% in the TAU group. Symptom remission was achieved in 35.2% of the E/RP group and 0% of the TAU group. There was no attrition and satisfaction was high; gains were maintained at 3 months.
Conclusions:
Even amongst children as young as 3 years, developmentally tailored E/RP is efficacious and well-tolerated in reducing OCD symptoms. Key adaptations for younger children include extensive parent involvement, targeting family accommodation, and frequent meetings while delivering a full course of E/RP.
Clinicaltrialsgov Identifier:
NCT01447966 http://clinicaltrials.gov/ct2/show/NCT01447966?term=ocd+and+st+petersburg&rank=1.
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