Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Research Domains
  1. Home
  3. Research Domains

Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Incidence Of Colonic Neoplasia In Patients With Serrated Polyposis Syndrome Who Undergo Annual Endoscopic Surveillance.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Incidence Of Colonic Neoplasia In Patients With Serrated Polyposis Syndrome Who Undergo Annual Endoscopic Surveillance.

    • Related Experiment Videos

    Incidence of colonic neoplasia in patients with serrated polyposis syndrome who undergo annual endoscopic surveillance.

    Yark Hazewinkel1, Kristien M A J Tytgat1, Susanne van Eeden2

    • 1Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

    Gastroenterology
    |March 25, 2014

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Annual endoscopic surveillance and polyp removal in serrated polyposis syndrome (SPS) patients effectively prevents colorectal cancer (CRC). This protocol, including prophylactic surgery for high-risk individuals, shows no significant morbidity.

    Keywords:
    Cancer PreventionColon CancerScreeningSerrated Neoplasia Pathway

    Related Experiment Videos

    Area of Science:

    • Gastroenterology
    • Oncology
    • Endoscopic Medicine

    Background:

    • Serrated polyposis syndrome (SPS) necessitates regular endoscopic surveillance for colorectal cancer (CRC) prevention.
    • Optimal surveillance strategies for SPS remain undefined.

    Purpose of the Study:

    • To evaluate a standardized endoscopic treatment protocol for SPS patients.
    • To assess the efficacy of annual surveillance and polyp removal in preventing CRC.

    Main Methods:

    • A prospective study followed 50 SPS patients undergoing annual colonoscopies with removal of polyps ≥3 mm.
    • Follow-up colonoscopies were scheduled annually post-clearance.
    • Primary outcomes included CRC and polyp incidence; secondary outcomes were complications and surgery rates.

    Main Results:

    • CRC was not detected in 41 patients (82%) achieving endoscopic clearance during a median 3.1-year follow-up.
    • After 3 surveillance colonoscopies, cumulative risks were 0% for CRC, 9% for advanced adenomas, and 34% for large serrated polyps.
    • Twelve patients (24%) underwent preventive surgery; no major complications occurred.

    Conclusions:

    • Annual endoscopic surveillance with complete polyp removal and timely prophylactic surgery prevents CRC in SPS patients without significant morbidity.
    • Close endoscopic surveillance is crucial due to the high risk of polyp recurrence in SPS.