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Published on: October 27, 2020
GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation
Depu Zhang1, Xiaowei Li1, Ziming Yao1
1Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Abstract:
The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer cells, MCF-7 human breast cancer cells and human breast cancer tissue. Baclofen, a GABABR agonist, significantly promoted 4T1 cells invasion and migration in vitro and metastasis in vivo, an event that was attenuated by GABABR antagonist CGP55845. Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway.
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