Related Experiment Video
Updated: May 1, 2026

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
Published on: February 8, 2017
The emerging role of MMP14 in brain tumorigenesis and future therapeutics
Ilya Ulasov1, Ruiyang Yi2, Donna Guo2
1Ivy Brain Tumor Center, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Abstract:
Glioblastoma is a malignant brain tumor of glial origin. These tumors are thought to be derived from astrocytic cells that undergo malignant transformation. A growing body of evidence suggests that upregulation of MMP expression plays a significant role in promoting glioma pathogenesis. Elevated expression of MMP14 not only promotes glioma invasion and tumor cell proliferation but also plays a role in angiogenesis. Despite the fact that levels of MMP14 correlate with breast cancer progression, the controversial role of MMP14 in gliomagenesis needs to be elucidated. In the present review, we discuss the role of MMP14 in glioma progression as well as the mechanisms of MMP14 regulation in the context of future therapeutic manipulations.
Related Concept Videos
The Tumor Microenvironment
Mitogens and the Cell Cycle
Role of Matrix Metalloproteases in Degradation of ECM
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

