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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
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Related Experiment Video

Updated: May 1, 2026

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
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Microfluidic-enabled liposomes elucidate size-dependent transdermal transport.

Renee R Hood1, Eric L Kendall2, Mariana Junqueira3

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, United States of America.

Plos One
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Small, nearly monodisperse liposomes (31-41 nm) show enhanced skin penetration compared to larger ones. These nanoscale vesicles efficiently cross the stratum corneum without rupture, indicating potential for transdermal drug delivery.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Dermatology

Background:

  • Transdermal drug delivery faces challenges due to the stratum corneum barrier.
  • Liposomes are promising carriers, but their transport properties are size-dependent.
  • Controlling liposome size is crucial for effective skin penetration.

Purpose of the Study:

  • To investigate the influence of liposome size on passive transdermal transport.
  • To evaluate the penetration capabilities of nanoscale lipid vesicles through the stratum corneum.
  • To determine the suitability of size-controlled liposomes for transdermal drug delivery.

Main Methods:

  • Microfluidic synthesis for precise liposome size control.
  • Investigation of passive transdermal transport of liposomes with varying diameters.
  • Multicolor fluorescence imaging to track liposome penetration and integrity.

Main Results:

  • Liposomes >105 nm were excluded from deeper skin layers.
  • Liposomes with mean diameters of 31-41 nm demonstrated significantly enhanced skin penetration.
  • Smaller liposomes rapidly traversed the stratum corneum without rupture, confirmed by imaging.

Conclusions:

  • Nanoscale liposomes with controlled, narrow size distribution facilitate enhanced transdermal transport.
  • Size is a critical factor determining the efficacy of liposomes as transdermal delivery vehicles.
  • These findings support the use of precisely engineered nanoscale liposomes for effective transdermal delivery of nanoparticle drugs.