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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

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Large retroperitoneal low-grade extraskeletal osteosarcoma.

Jiten Jaipuria¹, Ashok Kumar, Adla Satyanarayan Rao

¹Department of General Surgery, VMMC and Safdarjung Hospital, New Delhi, India.

BMJ Case Reports

|March 25, 2014

Summary

This report details the management of a rare retroperitoneal low-grade extraskeletal osteosarcoma. Surgical resection followed by chemotherapy resulted in a disease-free outcome after three years.

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Area of Science:

Oncology
Surgical Oncology
Medical Oncology

Background:

Low-grade extraskeletal osteosarcoma is exceptionally rare, with limited literature, particularly involving the retroperitoneum.
Management strategies for this neoplasm are not well-established due to its rarity and potential for dedifferentiation.

Observation:

A case of the largest reported retroperitoneal low-grade extraskeletal osteosarcoma (18.0 cm × 18.3 cm × 17.8 cm) in a 38-year-old male is presented.
The patient underwent surgical tumor excision.

Findings:

Post-operative treatment included six cycles of cisplatin and doxorubicin chemotherapy, administered every three weeks with granulocyte colony-stimulating factor support.
The patient achieved a disease-free status at the 3-year follow-up mark.

Implications:

This case highlights a successful multimodal treatment approach for a rare retroperitoneal tumor.
Further case reports and literature reviews are crucial for refining management protocols for low-grade extraskeletal osteosarcoma.