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Updated: May 1, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Regioselective electrophilic aromatic bromination: theoretical analysis and experimental verification
Hui-Jing Li1, Yan-Chao Wu2, Jian-Hong Dai3
1School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.
Abstract:
Electrophilic aromatic bromination is the most common synthetic method used to prepare aryl bromides, which are very useful intermediates in organic synthesis. To understand the experimental results in electrophilic aromatic brominations, ab initio calculations are used here for a tentative analysis of the positional selectivity. The calculated results agree well with the corresponding experimental data, and the reliability of the resulting positional selectivity was verified by the corresponding experimental data.
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