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Therapeutic plasmapheresis and haemostatic system.
S Ziemer1, E Roeseler, A Monike
1Institute of Pathological and Clinical Biochemistry, Hospital of Humboldt, University Berlin, GDR.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1988
Summary
Therapeutic plasmapheresis using membrane filters can reduce fibrinogen and antithrombin III (AT III) levels. Monitoring these factors before each procedure is crucial to prevent hemostatic system imbalances.
Area of Science:
- Hematology
- Nephrology
- Medical Technology
Background:
- Therapeutic plasmapheresis is a medical procedure used to remove plasma components.
- Membrane filtration is a common method for plasma separation.
- Understanding the impact on coagulation factors is essential for patient safety.
Purpose of the Study:
- To investigate the effects of membrane filter plasmapheresis on hemostatic parameters.
- To identify key coagulation factors affected by repeated plasmapheresis procedures.
- To establish guidelines for safe plasmapheresis protocols.
Main Methods:
- Investigated 38 patients undergoing 108 therapeutic plasmapheresis procedures.
- Utilized membrane filtration for plasma separation.
- Monitored levels of fibrinogen, antithrombin III (AT III), factors II, V, X, Hepato-Quick, Reptilase time, and thrombocyte count.
Main Results:
- Fibrinogen and AT III levels showed the most significant reduction after three plasma exchanges.
- Factors II, V, X, Hepato-Quick, Reptilase time, and thrombocyte count remained relatively stable.
- No bleeding or thrombotic events were observed in the patient cohort.
Conclusions:
- Repeated plasmapheresis significantly impacts fibrinogen and AT III levels.
- Close monitoring of fibrinogen and AT III is necessary before each plasmapheresis.
- This monitoring helps prevent dangerous imbalances in the hemostatic system.