Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

7.6K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
7.6K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.9K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.9K
Autophagy01:27

Autophagy

5.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.0K
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

99
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
99
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

1.8K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
1.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction.

Cell reports·2026
Same author

PSMD1 and myeloma: striking the proteasome from a new angle.

Blood·2026
Same author

The HIF-1α Pathway Regulates Satellite Cell Fate During Aging Through Histone Lactylation.

Aging cell·2026
Same author

Constructing the program theory: an implementation science approach to understanding a successful interdisciplinary team-based model of rheumatology care.

Implementation science communications·2026
Same author

Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.

The journals of gerontology. Series B, Psychological sciences and social sciences·2025
Same author

"It's Like a One-Stop-Shop": A Qualitative Study Exploring Patient Experiences With Interdisciplinary Team-Based Rheumatology Care.

The Journal of rheumatology·2025
Same journal

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

Frontiers in immunology·2026
Same journal

Circadian control of immune homeostasis in cardiovascular health and disease.

Frontiers in immunology·2026
Same journal

An IHC-derived TLS-CD8-macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC.

Frontiers in immunology·2026
Same journal

AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.

Frontiers in immunology·2026
Same journal

Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.

Frontiers in immunology·2026
Same journal

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.3K

Autophagy in plasma cell pathophysiology.

Laura Oliva1, Simone Cenci2

  • 1Division of Genetics and Cell Biology, San Raffaele Scientific Institute , Milan , Italy.

Frontiers in Immunology
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Autophagy, a cellular recycling process, is crucial for plasma cell differentiation and antibody production. It helps maintain cell viability and supports long-lived plasma cells, impacting adaptive immunity and diseases like multiple myeloma.

Keywords:
XBP-1antibodyautophagyendoplasmic reticulummultiple myelomaplasma cellproteostasisunfolded protein response

More Related Videos

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

11.4K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

10.5K

Related Experiment Videos

Last Updated: May 1, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.3K
Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

11.4K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

10.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Plasma cells (PCs) are essential for antibody (Ab)-mediated immunity, undergoing significant structural and functional changes during differentiation.
  • Cellular stress is inherent to PC differentiation, and autophagy is a key stress adaptation mechanism.
  • Autophagy has emerging roles in various immune processes, including lymphocyte development and antigen presentation.

Purpose of the Study:

  • To elucidate the novel role of autophagy in the differentiation and function of plasma cells.
  • To understand how autophagy regulates key factors and cellular components during plasma cell development.

Main Methods:

  • Investigated the impact of autophagy on Blimp-1 expression and immunoglobulin production in differentiating B cells.
  • Analyzed the effect of autophagy on endoplasmic reticulum size and associated stress signaling (XBP-1).
  • Assessed the role of autophagy in sustaining antibody responses and long-lived plasma cell populations in vivo.

Main Results:

  • Autophagy selectively controls the expression of Blimp-1 and immunoglobulins by regulating endoplasmic reticulum size and stress.
  • This regulation by autophagy is vital for optimizing energy metabolism and cell viability during plasma cell differentiation.
  • Autophagy is demonstrated to be essential for sustaining antibody production and the persistence of long-lived plasma cells.

Conclusions:

  • Autophagy plays a critical, previously unrecognized role in plasma cell differentiation and function.
  • Autophagy optimizes plasma cell energetics and viability, thereby sustaining effective antibody responses.
  • Autophagy is fundamental for establishing long-lived plasma cells and has implications for immune diseases, including multiple myeloma.