Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determinants of cardiorespiratory fitness after successfully reperfused ST-elevation myocardial infarction.

Current problems in cardiology·2026
Same author

Real-World Analysis of Malnutrition and 1-Year Mortality in Patients Treated With Temporary Mechanical Circulatory Support.

JACC. Heart failure·2026
Same author

Vasopressin in cardiogenic shock: pathophysiology, clinical evidence, and therapeutic perspectives.

ESC heart failure·2026
Same author

Residual inflammatory risk and clinical outcomes after contemporary percutaneous coronary intervention: a systematic review and meta-analysis.

Scientific reports·2026
Same author

Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis.

Circulation·2026
Same author

Resolution of Systemic Inflammation in Patients With Recently Decompensated Heart Failure With Reduced Ejection Fraction With and Without Interleukin-1 Blockade by Anakinra.

Circulation. Heart failure·2025

Related Experiment Video

Updated: May 1, 2026

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
08:16

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

7.3K

Decellularized matrices for cardiovascular tissue engineering.

Francesco Moroni1, Teodelinda Mirabella2

  • 1Universita' Vita-Salute San Raffaele Milan, 20132, Italy.

American Journal of Stem Cells
|March 25, 2014
PubMed
Summary
This summary is machine-generated.

Decellularized matrices promote tissue regeneration for cardiovascular repair, outperforming synthetic grafts by enhancing biointegration. Research reviews techniques and extracellular matrix roles in this process.

Keywords:
Cardiovasculardecellularizationmatrixprogenitorstissue engineering

More Related Videos

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications
08:41

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

8.4K
Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies
08:10

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Published on: March 21, 2019

6.2K

Related Experiment Videos

Last Updated: May 1, 2026

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
08:16

Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies

Published on: November 5, 2016

7.3K
Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications
08:41

Processing of Human Cardiac Tissue Toward Extracellular Matrix Self-assembling Hydrogel for In Vitro and In Vivo Applications

Published on: December 4, 2017

8.4K
Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies
08:10

Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies

Published on: March 21, 2019

6.2K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Surgery

Background:

  • Cardiovascular disease (CVD) is a major cause of mortality.
  • Current synthetic grafts for cardiovascular repair lack biointegration.
  • Decellularized matrices offer a biological alternative for tissue regeneration.

Purpose of the Study:

  • To review decellularization techniques for cardiovascular tissues.
  • To evaluate the biological performance of decellularized grafts.
  • To highlight the role of extracellular matrix (ECM) in host response and tissue regeneration.

Main Methods:

  • Review of existing literature on decellularization protocols (osmotic shock, detergents, enzymatic treatments).
  • Analysis of studies on the in vivo performance of decellularized heart, valves, and vessels.
  • Examination of the impact of ECM components on cellular interactions and tissue outcomes.

Main Results:

  • Decellularization effectively removes cellular components but can compromise ECM structure.
  • Decellularized matrices can support endothelial cell migration, proliferation, and mural cell recruitment.
  • ECM composition influences host response, determining tissue regeneration versus graft failure.

Conclusions:

  • Decellularized matrices show promise for cardiovascular tissue engineering due to their biointegration capabilities.
  • Optimizing decellularization protocols is crucial for preserving ECM integrity and function.
  • Understanding ECM-host interactions is key to developing effective regenerative cardiovascular grafts.