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Related Experiment Video

Updated: May 1, 2026

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies
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Kindlin-3 in the immune system.

Susanna C Fagerholm1, Hwee San Lek2, Vicky L Morrison2

  • 1Institute of Biotechnology, University of Helsinki Finland ; Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee UK.

American Journal of Clinical and Experimental Immunology
|March 25, 2014
PubMed
Summary

Kindlin-3 protein regulates integrin activation in immune cells. Mutations cause leukocyte adhesion deficiency type III (LAD-III), impacting platelet and leukocyte function, leading to bleeding and infections.

Keywords:
KindlinLAD-IIIT celladhesionintegrin

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Area of Science:

  • Biochemistry
  • Immunology
  • Genetics

Background:

  • Kindlin-3 is a focal adhesion protein crucial for integrin function.
  • Unlike other kindlins, kindlin-3 is primarily found in hematopoietic cells.
  • Defects in kindlin-3 cause leukocyte adhesion deficiency type III (LAD-III).

Purpose of the Study:

  • To review the function of kindlin-3 in integrin activation.
  • To explore the role of kindlin-3 in immune cell activities.

Main Methods:

  • Literature review of kindlin-3 research.
  • Analysis of genetic mutations causing LAD-III.
  • Examination of integrin activation pathways.

Main Results:

  • Kindlin-3 is essential for activating beta1, beta2, and beta3 integrins.
  • Kindlin-3 deficiency impairs platelet aggregation and leukocyte adhesion.
  • LAD-III patients exhibit severe bleeding and recurrent infections.

Conclusions:

  • Kindlin-3 plays a vital role in immune cell function and hemostasis.
  • Understanding kindlin-3 is key to addressing LAD-III.
  • Targeting kindlin-3 pathways may offer therapeutic potential.