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Updated: May 1, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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The role of transcription factors in prostate cancer and potential for future RNA interference therapy

Kathleen A Fitzgerald1, James C Evans, Joanna McCarthy

  • 1PhD student in gene delivery, University College Cork, School of Pharmacy, Cavanagh Pharmacy Building , Cork , Ireland.

Expert Opinion on Therapeutic Targets
|March 26, 2014
PubMed
Abstract

Insights

Transcription factors are promising therapeutic targets for advanced prostate cancer. RNA interference (RNAi) strategies targeting these factors may improve treatment outcomes and reduce disease progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer remains a leading cause of cancer-related death in men.
  • Current treatments for advanced prostate cancer offer limited survival benefits.
  • Transcription factors regulate gene expression and are implicated in cancer development.

Purpose of the Study:

  • To review transcription factors as potential therapeutic targets for prostate cancer.
  • To explore the application of RNA interference (RNAi) in targeting these factors.
  • To identify key transcription factors involved in prostate cancer drug resistance, progression, and metastasis.

Main Methods:

  • Literature review focusing on transcription factors in prostate cancer.
  • Analysis of transcription factors as targets for RNA interference (RNAi) therapy.
  • Identification of transcription factors linked to drug resistance, disease progression, and metastasis.

Main Results:

  • Transcription factors play critical roles in prostate cancer's advanced stages.
  • Several transcription factors have been identified as key drivers of drug resistance, progression, and metastasis.
  • These factors represent viable targets for future RNAi-based therapies.

Conclusions:

  • Targeting specific transcription factors with RNA interference (RNAi) offers a novel therapeutic strategy for prostate cancer.
  • This approach has the potential to enhance current chemotherapy regimens.
  • Successful targeting may lead to slowed disease progression, reduced metastasis, and improved patient outcomes.
Keywords:
RNA interferenceY-box-binding protein-1activator protein-1androgen receptordelivery of RNAieIF4Eforkhead box M1gene therapynuclear factor κ Bprostate cancerserum response factorsignal transducer and activator of transcriptionspecificity protein 1transcription factor

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