Related Experiment Video
Updated: May 1, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
Neuroticism relates to daytime wakefulness and sleep devaluation via high neurophysiological efficiency in the
Takuya Yoshiike1, Kenichi Kuriyama, Motoyasu Honma
1Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Section of Psychiatry and Behavioral Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Abstract:
Higher wake promotion against sleep drive boosts cognitive processing, but it also seems to increase the risk of insomnia by reinforcing an obsession with sleep in neurotic patients. To explore whether a personality trait of neuroticism simultaneously facilitates wake-promoting ability and sleep devaluation via a common regional prefrontal function under a sleep-restricted condition, working memory tasks were administered to 49 healthy humans after a 2-h sleep restriction. Higher wake-promoting ability demonstrated in a high-load task was correlated with lower bilateral prefrontal activation, as measured by near-infrared spectroscopy. Structural equation modeling revealed that neuroticism predicts sleep devaluation and wake-promoting ability via left and right regional prefrontal efficiency, respectively. Our results indicate that neuroticism-related neural efficiency increases resilience to sleepiness, but decreases sleep satisfaction.
More Related Videos
Related Concept Videos
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
High-Level and Low-Level Awareness
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Narcolepsy
Understanding Consciousness
Sleep, a crucial state, is characterized by reduced...

