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Related Concept Videos

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Related Experiment Video

Updated: May 1, 2026

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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What determines human body odour?

Kaoru Hamada1, Sanehito Haruyama, Takashi Yamaguchi

  • 1Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.

Experimental Dermatology
|March 26, 2014
PubMed
Summary
This summary is machine-generated.

Genetic variations in the ABCC11 gene influence body odor. Researchers found that the ABCC11 transporter facilitates the transport of a specific odorant precursor, aiding in the understanding of human malodor development.

Keywords:
3-methyl-3-sulfanylhexanolABCC11GGT1odor

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Area of Science:

  • Biochemistry
  • Human Genetics
  • Dermatology

Background:

  • Human body odor and earwax type are genetically determined by a single-nucleotide polymorphism (SNP) in the ABCC11 gene.
  • The precise molecular mechanisms linking ABCC11 gene variants to human malodor remain incompletely understood.

Purpose of the Study:

  • To elucidate the molecular pathway through which ABCC11 gene variants influence human body odor.
  • To investigate the role of the ABCC11 transporter in the metabolism of odorant precursors in apocrine sweat glands.

Main Methods:

  • Investigated the transport activity of the ABCC11 transporter for Cys-Gly-3-methyl-3-sulfanylhexanol (3M3SH) and its glutathione conjugate (SG-3MSH).
  • Assessed the expression and activity of gamma-glutamyl transferase 1 (GGT1) in apocrine sweat glands.

Main Results:

  • The ABCC11 transporter did not uptake 3M3SH directly.
  • ABCC11 efficiently transported the glutathione conjugate of 3MSH (SG-3MSH).
  • Abundant expression of GGT1 in apocrine sweat glands suggests it processes SG-3MSH into 3M3SH.

Conclusions:

  • A potential molecular pathway for human body odor involving ABCC11-mediated transport of SG-3MSH and subsequent GGT1 processing has been identified.
  • These findings offer insights into the pharmacogenetics of human body odor.
  • The study may facilitate the development of novel deodorant products targeting this pathway.