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Intradetrusor onabotulinumtoxinA for overactive bladder.
Lisa H Jambusaria1, Roger R Dmochowski
1Vanderbilt University Medical Center, Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology , B-1100 Medical Center North, Nashville, TN 37232 , USA +1 615 322 8968 ; +1 615 343 8881 ; lisa.h.jambusaria@vanderbilt.edu.
Expert Opinion on Biological Therapy
|March 26, 2014
Summary
OnabotulinumtoxinA (onabotA) offers an effective and well-tolerated treatment for overactive bladder, especially for patients unresponsive to traditional therapies. This alternative shows promise for improved compliance and symptom resolution.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder affects 11.8% of the population, with high discontinuation rates for anticholinergic therapy.
- Intradetrusor onabotulinumtoxinA (onabotA) is emerging as an efficacious and well-tolerated alternative.
Purpose of the Study:
- To evaluate the efficacy and tolerability of onabotA for idiopathic overactive bladder.
- To review current literature on onabotA's use in treating overactive bladder.
Main Methods:
- Literature search and review of studies on onabotA for overactive bladder.
- Evaluation of data stemming from its use in neurogenic detrusor overactivity.
Main Results:
- Randomized clinical trials demonstrate onabotA's effectiveness in non-neurogenic bladder.
- OnabotA shows promising efficacy in patients who have failed traditional pharmacotherapy.
Conclusions:
- Intradetrusor onabotA is an effective treatment for overactive bladder, particularly after pharmacotherapy failure.
- This therapy may offer superior patient compliance and higher rates of complete symptom resolution.
- Further long-term studies are warranted to confirm sustained efficacy and safety.
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