Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

31.3K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
31.3K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.3K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
Spermatogenesis01:41

Spermatogenesis

91.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.0K
Primary Motives: Sleep, Sex, and Pain Avoidance01:24

Primary Motives: Sleep, Sex, and Pain Avoidance

8.1K
Primary motives such as sleep, sex, and pain avoidance are crucial drivers of behavior in humans and animals. These motives ensure survival, reproductive success, and overall well-being by prompting actions that meet essential bodily needs.
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
8.1K
Penis01:29

Penis

50.8K
The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
50.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1.

Redox biology·2025
Same author

Influence of Cementation Strategies on the Incidence of Fiber Post Debonding in Root Canal Treated Teeth: A Systematic Review and Meta-Analysis.

The European journal of prosthodontics and restorative dentistry·2024
Same author

Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies.

Pharmacological research·2023
Same author

Effect of Polymerization on the Color of Resin Composites.

Operative dentistry·2022
Same author

Impact of SARS-CoV-2 on dentistry: a review of literature.

European review for medical and pharmacological sciences·2022
Same author

Multimodality imaging of the ischemic right ventricle: an overview and proposal of a diagnostic algorithm.

The international journal of cardiovascular imaging·2021

Related Experiment Video

Updated: May 1, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.4K

Gas what: NO is not the only answer to sexual function.

G Yetik-Anacak1, R Sorrentino, A E Linder

  • 1Department of Pharmacology, Faculty of Pharmacy, Ege University, İzmir, Turkey.

British Journal of Pharmacology
|March 26, 2014
PubMed
Summary

Erectile dysfunction (ED) involves nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These gasotransmitters play key roles in sexual function and may offer new ED treatment targets beyond PDE-5 inhibitors.

More Related Videos

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

14.4K
Analytical Techniques for Assaying Nitric Oxide Bioactivity
11:28

Analytical Techniques for Assaying Nitric Oxide Bioactivity

Published on: June 18, 2012

17.7K

Related Experiment Videos

Last Updated: May 1, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.4K
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

14.4K
Analytical Techniques for Assaying Nitric Oxide Bioactivity
11:28

Analytical Techniques for Assaying Nitric Oxide Bioactivity

Published on: June 18, 2012

17.7K

Area of Science:

  • Physiology
  • Pharmacology
  • Pathophysiology

Background:

  • Erectile dysfunction (ED) is increasingly recognized as an early marker of systemic endothelial dysfunction and cardiovascular disease.
  • Nitric oxide (NO) is crucial for endothelial relaxation and erectile function.
  • Carbon monoxide (CO) and hydrogen sulfide (H2S) are other gasotransmitters whose roles in physiological and pathophysiological conditions are being investigated.

Purpose of the Study:

  • To review the roles of NO, CO, and H2S in the physiology, pharmacology, and pathophysiology of male sexual function, specifically erectile function.
  • To examine the soluble guanylyl cyclase/cGMP pathway as a common target for these gasotransmitters.
  • To highlight alternative therapeutic strategies for ED.

Main Methods:

  • Literature review focusing on the roles of NO, CO, and H2S in erectile function.
  • Analysis of studies investigating the soluble guanylyl cyclase/cGMP pathway.
  • Examination of alternative ED treatment mechanisms.

Main Results:

  • NO, CO, and H2S are involved in the regulation of erectile function.
  • These gasotransmitters share the soluble guanylyl cyclase/cGMP pathway as a common molecular target.
  • Some patients do not respond to current ED treatments like PDE-5 inhibitors, necessitating alternative approaches.

Conclusions:

  • The three gasotransmitters (NO, CO, H2S) play significant roles in erectile function and dysfunction.
  • Targeting these gasotransmitters may offer complementary or alternative therapeutic strategies for ED.
  • Further research into the coordinated roles of these mediators could lead to novel ED treatments.