Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

49
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
49
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

40
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
40

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

Navigated percutaneous placement of cervical pedicle screws: An anatomical feasibility study.

Brain & spine·2025
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same journal

GWAS of Second-Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Basophil Activation Test Provides Additional Diagnostic Value Beyond Ara h 2-Specific IgE Testing in Peanut Allergic Adults.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Characterisation of Allergen Profiles in Commercial Egg Products to Inform Oral Immunotherapy Strategies in Egg Allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Allergic Diseases and Risk of Incident Autoimmune Diseases: Phenotype-Specific Patterns and Multimorbidity Effects in a Nationwide Cohort.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Determinants of Total and Inhaled Allergen-Specific Immunoglobulin E in the Middle-Aged and Elderly Population.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Rhinitis-Related Healthcare Utilization in Colombian Adults, 2015-2024.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

1.4K

Epithelial function and dysfunction in asthma.

M Loxham1, D E Davies, C Blume

  • 1Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, Hampshire, UK.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|March 26, 2014
PubMed
Summary
This summary is machine-generated.

Asthma is a complex immune disorder, not just allergic. The airway epithelium plays a critical role in asthma development and may offer new therapeutic targets.

More Related Videos

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

26.0K
Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
08:42

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

5.3K

Related Experiment Videos

Last Updated: May 1, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
07:40

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

Published on: February 21, 2025

1.4K
Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies
14:48

Flow Cytometric Isolation of Primary Murine Type II Alveolar Epithelial Cells for Functional and Molecular Studies

Published on: December 26, 2012

26.0K
Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
08:42

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

5.3K

Area of Science:

  • Immunology
  • Pulmonology
  • Epithelial Biology

Background:

  • The traditional view of asthma as solely a Th2-mediated allergic disease is evolving.
  • Emerging evidence suggests asthma is a complex immune disorder involving both innate and adaptive responses, leading to clinical heterogeneity.
  • Environmental exposures are strongly linked to asthma risk, highlighting the role of the airway epithelium as the primary interface.

Purpose of the Study:

  • To explore the complex role of the airway epithelium in asthma pathogenesis.
  • To investigate how epithelial barrier dysfunction contributes to asthma development.
  • To identify the airway epithelium as a potential target for novel asthma therapies.

Main Methods:

  • Review of current literature on asthma immunology and epithelial biology.
  • Analysis of epidemiological data linking environmental factors to asthma.
  • Examination of genetic and epigenetic factors influencing epithelial function in asthma.

Main Results:

  • The airway epithelium is crucial in responding to environmental insults and maintaining homeostasis.
  • Defects in epithelial regulatory mechanisms compromise barrier function, increasing susceptibility to asthma.
  • Genetic polymorphisms and environmental epigenetics in bronchial epithelium are associated with asthma.

Conclusions:

  • Asthma pathogenesis is more complex than previously thought, involving intricate epithelial responses.
  • The airway epithelium is a key player in asthma, influencing disease development and phenotype.
  • Targeting epithelial dysfunction offers a promising avenue for developing new asthma treatments that address underlying mechanisms and prevent airway remodeling.