Related Experiment Video
Updated: May 1, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
938
Extensive prurigo nodularis: characterization and etiology.
Wei Sheng Tan1, Hong Liang Tey
1National Skin Centre, Singapore, Singapore.
Dermatology (Basel, Switzerland)
|March 26, 2014
Summary
This study found that all patients with extensive prurigo nodularis (PN) had identifiable causes for their itching. Dermatological conditions, particularly eczema, were the most common triggers in this Asian cohort.
Area of Science:
- Dermatology
- Clinical Medicine
- Epidemiology
Background:
- Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense itching and excoriated nodules.
- Multiple underlying etiologies have been reported for PN, but data from Asian populations are limited.
Purpose of the Study:
- To analyze the demographics, clinical distribution, and underlying etiologies of prurigo nodularis in an Asian cohort.
- To identify common pruritus-associated factors in patients with extensive PN.
Main Methods:
- A 1-year retrospective study was conducted.
- Included patients had extensive prurigo nodularis lesions (≥10).
- Data were collected from patients attending a specialized itch clinic.
Main Results:
- 37 patients (46% male, median age 53 years) were analyzed.
- All patients had an identifiable etiologic factor associated with pruritus.
- Dermatological diseases (82%) were the most common cause, with endogenous eczema (54%) being predominant.
- Systemic diseases accounted for 38% of cases.
Conclusions:
- Identifiable factors associated with pruritus were present in all patients with extensive PN.
- Dermatological conditions were the predominant etiology, regardless of single or multiple contributing factors.
- A significant proportion of patients had underlying systemic causes for their prurigo nodularis.
Related Concept Videos
01:11Papillary Dermis
5.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.8K
01:23Skin Diseases and Disorders
5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
01:30Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
01:21Accessory Structures of the Skin: Sebaceous Glands
5.5K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
5.5K
01:27Acne Infection
94
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
94
01:15Reticular Dermis
4.6K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.6K