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Updated: May 1, 2026

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
Regenerative medicine. Knocking on the door to successful hepatocyte transplantation
Stuart J Forbes1, Malcolm R Alison2
1MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh EH16 4UU, UK.
Abstract:
With the ongoing shortage of livers available for transplantation, attention has turned to cell-based approaches to support liver function and enable liver regeneration. However, hepatocyte transplantation is beset with problems and a clinically adoptable strategy is lacking. How can a plentiful supply of hepatocyte-like cells with long-term proliferation be generated?
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