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MCM10: one tool for all-Integrity, maintenance and damage control

Yee Mon Thu1, Anja-Katrin Bielinsky1

  • 1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.

Seminars in Cell & Developmental Biology
|March 26, 2014
PubMed

Insights

Minichromosome maintenance protein 10 (Mcm10) is crucial for DNA replication by acting as a scaffold. Its loss triggers cellular rescue pathways to maintain genome integrity.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Minichromosome maintenance protein 10 (Mcm10) is an essential replication factor.
  • It is required for the activation of the Cdc45:Mcm2-7:GINS helicase complex.
  • Mcm10 binds both double-stranded (ds) and single-stranded (ss) DNA, which is vital for its function.

Purpose of the Study:

  • To review the structure and function of Mcm10.
  • To explain Mcm10's role in DNA replication and genome integrity.

Main Methods:

  • Literature review of Mcm10's structure and function.
  • Analysis of Mcm10's interactions with other replication proteins.
  • Examination of cellular responses to Mcm10 loss.

Main Results:

  • Mcm10 acts as an oligomeric scaffold, coordinating DNA unwinding and synthesis.
  • It interacts with DNA polymerase-α and proliferating cell nuclear antigen during DNA elongation.
  • Loss of Mcm10 activates checkpoint, DNA repair, and SUMO-dependent rescue pathways.

Conclusions:

  • Mcm10 is essential for coordinating DNA replication.
  • It plays a critical role in maintaining genome integrity by preventing replication stress and chromosome breakage.
Keywords:
Cancer mutationsDNA replicationGenome integrityMcm10OB-foldSTUbL

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