Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Cross-reactivity

Cross-reactivity

Hypothalamic-Pituitary Axis

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

PCR

PCR

Humoral Immune Responses

Humoral Immune Responses

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy.

JAMA network open·2026

Same author

Subjective cognitive complaints and decline among aging individuals with prior repetitive head impact exposure.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same author

CTE has multiple pathologic variants that might relate to different clinical symptom presentation.

Acta neuropathologica·2026

Same author

Validity of the NINDS traumatic encephalopathy syndrome criteria for predicting chronic traumatic encephalopathy.

medRxiv : the preprint server for health sciences·2026

Same author

Associations Between Cumulative Head Trauma and Self-Reported Parkinsonism and Parkinson's Disease in Former Soccer Players.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration.

Acta neuropathologica·2026

Search research articles

Related Experiment Video

Updated: May 1, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Author's reply: To PMID 19535999

¹Boston, Massachusetts.

Journal of Neuropathology and Experimental Neurology

|March 26, 2014

Summary

No abstract available in PubMed .

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

Related Experiment Videos

Last Updated: May 1, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024