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Sporadic Creutzfeldt-Jakob disease (sCJD) with asymmetric findings
Madhuri Khilari1, Sunitha Vellathussery Chakkalakkoombil, Vaibhav Wadwekar
1Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Abstract:
We report a case of a patient with probable Creutzfeldt-Jakob disease (CJD) who had psychiatric manifestation in the form of withdrawn depressive behaviour at the onset, followed by rapidly progressive ataxia, parkinsonism, mutism and cognitive decline with generalised asynchronous multifocal myoclonic jerks. His EEG exhibited focal (lateralised) periodic triphasic sharp waves on the background of generalised delta slowing, which later on became more generalised. MRI of the brain showed hyperintensity in basal ganglia with cortical ribbon sign in bilateral frontal region. Clinical course showed progressive deterioration to an akinetic-abulic stage. He died 2 months after the onset of symptoms.
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