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Updated: May 1, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
GWAS-identified common variants for obesity are not associated with the risk of developing colorectal cancer
Juan Sainz1, Bernd Frank1, Miguel I da Silva Filho1
1Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
Background:
Observational studies have consistently associated obesity with colorectal cancer risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer.
Methods:
We conducted a comprehensive population-based case-control study in 1,792 German colorectal cancer cases and 1,805 controls to explore associations between 28 obesogenic variants identified through genome-wide association studies (GWAS) and colorectal cancer risk. We also evaluated interactions between polymorphisms and body mass index (BMI), type II diabetes (T2D), and gender.
Results:
No evidence of association between obesogenic variants and colorectal cancer risk was observed after correction for multiple testing. There was only a remarkable interaction between the LTArs1041981 polymorphism and gender, which modified the risk of colorectal cancer [Pinteraction = 0.002; males: odds ratio (OR), 1.14; 95% confidence intervals (CI), 1.00-1.30 vs. females: OR, 0.83; 95% CI, 0.71-0.97].
Conclusions:
Our findings showed that obesogenic variants are not a major pathogenetic risk factor for colorectal cancer.
Impact:
This comprehensive population-based case-control study does not provide evidence of a shared genetic component between obesity and colorectal cancer.
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