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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development

Eric D Shah1, Brandon M A Fisch, Robert J Arceci

  • 1Cancer Center and Departments of Cell Biology and Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, STOP 9445, Lubbock, TX, 79430, USA.

Cancer Chemotherapy and Pharmacology
|March 26, 2014
PubMed
Abstract

Insights

The DrugPath database helps researchers find cancer drugs in development by cataloging 2,081 programs targeting 722 molecular and genetic markers. This resource aids in identifying potential oncology treatments for preclinical studies.

Area of Science:

  • Oncology
  • Genomics
  • Drug Discovery

Background:

  • Academic research generates vast cancer genomic and gene expression data.
  • This data can reveal novel molecular targets for cancer therapies.
  • Identifying investigational drugs requires knowledge of both academic and commercial development pipelines.

Purpose of the Study:

  • To introduce DrugPath, a free database for academic researchers.
  • To facilitate the identification of potential drug candidates targeting specific molecular targets.
  • To support preclinical research by connecting academic labs with drugs in development.

Main Methods:

  • Developed the DrugPath database (http://www.drugpath.org).
  • Integrated DrugPath data with the Michigan Molecular Interactions (http://mimi.ncibi.org) gene-gene interaction map.
  • Enabled identification of agents targeting molecular pathways of interest.

Main Results:

  • The database contains 2,081 drug development programs.
  • It covers 751 drug sponsors and 722 molecular and genetic targets.
  • DrugPath links molecular targets with drugs in development.

Conclusions:

  • DrugPath serves as a valuable resource for academic investigators.
  • It aids in identifying and acquiring drugs for specific molecular targets.
  • Facilitates biological and preclinical therapeutic studies in oncology.

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