Related Experiment Video

Updated: May 1, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

13.1K

Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome

Angela Bauer1, Sebastian Loos, Carola Wehrmann

  • 1Department of Pediatrics, University Medical Center Hamburg, Hamburg, Germany.

Pediatric Nephrology (Berlin, Germany)
|March 26, 2014
PubMed

Insights

Pediatric hemolytic uremic syndrome (HUS) from E. coli O104:H4 frequently caused neurological issues, but most patients recovered well with rare major long-term neurological problems.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Disease Epidemiology

Background:

  • Analyzing neurological involvement and outcomes in pediatric patients with hemolytic uremic syndrome (HUS).
  • Focusing on the 2011 epidemic caused by Escherichia coli O104:H4.

Observation:

  • Neurological symptoms were present in 28% of pediatric HUS patients.
  • Electroencephalography (EEG) and magnetic resonance imaging (MRI) revealed abnormalities in affected patients.
  • Neuropsychological testing (WISC IV) was conducted during follow-up.

Findings:

  • High incidence of EEG abnormalities, even in patients without overt neurological signs.
  • Cranial MRI showed abnormalities in 5 out of 9 patients with neurological involvement.
  • While 67% reported reduced performance at 3 months, only 44% did at 6 months.
  • Patients with neurological involvement had a slightly lower global intelligence quotient.

Implications:

  • Neurological involvement is common in pediatric HUS but typically resolves.
  • Early detection and monitoring of neurological function are crucial.
  • Long-term neuropsychological outcomes are generally favorable, suggesting effective management strategies.
Abstract

More Related Videos

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

680
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.7K

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
15
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
22
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
74
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
149