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Related Experiment Video

Updated: May 1, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes.

Timothy Tay¹, Steven Bak Siew Wong, Kesavan so Sittampalam

¹Department of Pathology, Singapore General Hospital, 20 College Road, Level 10, Diagnostics Tower, The Academia, Singapore 169856. timothy.tay@mohh.com.sg.

Singapore Medical Journal

|March 26, 2014

Summary

Clear cell chondrosarcoma, a rare low-grade malignancy, often mimics benign conditions radiologically. This case highlights diagnostic challenges due to atypical features resembling avascular necrosis and aneurysmal bone cysts.

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Area of Science:

Orthopedic Oncology
Radiology
Pathology

Background:

Clear cell chondrosarcoma is a rare, low-grade malignant cartilaginous tumor.
Its clinical and radiological presentation can mimic benign bone lesions, complicating diagnosis.

Observation:

A case of clear cell chondrosarcoma in the proximal femur presented with atypical features.
Initial radiographs suggested chronic avascular necrosis, posing a diagnostic challenge.

Findings:

The tumor exhibited extensive aneurysmal bone cyst-like changes, a rare histological finding.
These changes further confounded the interpretation of radiological findings.

Implications:

This case underscores the importance of considering rare differentials in bone tumors.
Atypical radiological presentations require thorough histopathological evaluation for accurate diagnosis and treatment planning.