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Updated: May 1, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes
Timothy Tay1, Steven Bak Siew Wong, Kesavan so Sittampalam
1Department of Pathology, Singapore General Hospital, 20 College Road, Level 10, Diagnostics Tower, The Academia, Singapore 169856. timothy.tay@mohh.com.sg.
Abstract:
Clear cell chondrosarcoma is a rare cartilaginous tumour of low-grade malignancy. Although it has a characteristic histological appearance, its radiological features and clinical presentation often mimic a benign lesion. Herein, we describe the case of a patient with a clear cell chondrosarcoma of the right proximal femur that had an atypical appearance of chronic avascular necrosis on initial plain radiographs, which made preoperative diagnosis a challenge. In addition, the tumour also had extensive areas of aneurysmal bone cyst-like changes, which is not only a rare histologic phenomenon in clear cell chondrosarcoma, but also a confounding factor in the interpretation of the radiologic findings.
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