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Growth and antigenic characteristics of basal cell carcinoma in culture
M Bradbeer1, A J Bourne, H Ayberk
1Monash University Department of Medicine, Melbourne, Australia.
Archives of Dermatological Research
|January 1, 1988
Abstract:
Basal cell carcinomas (BCCs) were cultured using an explant method and compared with normal cultured skin. Immunohistochemical staining revealed reduced beta 2 microglobulin uptake by BCCs in frozen section, but normal staining of the tumours in culture. In culture, fibronectin was detected on the cell surface of normal keratinocytes but not on BCCs. The above differences may explain some of the behaviour of BCCs in vivo.