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Epithelioid cell histiocytoma: a new entity
E W Jones1, R Cerio, N P Smith
1Institute of Dermatology, United Medical School of Guy's Hospital, London, U.K.
The British Journal of Dermatology
|February 1, 1989
Summary
A novel histiocytoma type presents as solitary nodules, often on lower limbs. Characterized by large, angulated epithelioid cells, it differs from Spitz nevi and shows typical histiocytoma immunohistochemistry, including factor XIIIa expression.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Histiocytomas are a group of skin tumors.
- A distinct clinical and cytologic presentation of a histiocytoma is described.
Purpose of the Study:
- To describe a previously unrecognized type of histiocytoma.
- To differentiate this entity from Spitz nevi and other histiocytomas.
Main Methods:
- Clinical and cytologic examination of 19 lesions.
- Immunohistochemical analysis using factor XIIIa antibody.
Main Results:
- Solitary, elevated, vascular-appearing nodules on the lower limb were common.
- Lesions contained large, angulated epithelioid cells.
- Immunohistochemistry showed factor XIIIa expression in approximately 50% of cells, similar to ordinary histiocytomas.
Conclusions:
- This represents a distinct histiocytoma subtype.
- It can be distinguished from Spitz nevi based on cellular morphology and immunohistochemistry.
- Factor XIIIa expression supports its classification as a histiocytoma.