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Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?
G L Millhauser1, E E Salpeter, R E Oswald
1Department of Pharmacology, New York State College of Veterinary Medicine Cornell University, Ithaca 14853.
Biophysical Journal
|December 1, 1988
Abstract:
Lifetime probability density functions from single-channel recording are usually assumed to follow a multiexponential form. The amplitudes and rate constants for each exponential component are presumed to be independent. We have explored this assumption and have found a correlation between the amplitudes and the rate constants in certain cases. We examine this correlation and the possibility that other functional forms may also properly describe these distribution functions.