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Iron status and febrile seizure- a case control study in children less than 3 years

Mansour Sadeghzadeh1, Parisa Khoshnevis Asl1, Esrafil Mahboubi2

  • 1Assistant Professor of Pediatric, Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran.

Iranian Journal of Child Neurology
|March 26, 2014
PubMed

Insights

Iron deficiency, not anemia, is more common in children experiencing febrile seizures. This study found a higher prevalence of iron deficiency indicators in children with febrile seizures compared to healthy controls.

Area of Science:

  • Pediatric Neurology
  • Hematology

Background:

  • Febrile seizures are common childhood neurological events.
  • Iron deficiency anemia is a proposed, though not fully understood, factor in febrile seizure pathogenesis.

Purpose of the Study:

  • To investigate the association between iron deficiency anemia and febrile seizures in children aged 6 months to 3 years.
  • To compare iron status markers in children with febrile seizures versus a healthy control group.

Main Methods:

  • Assessed hemoglobin (Hb), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC), and SI/TIBC ratio.
  • Compared 100 children with febrile seizures to 100 healthy children.

Main Results:

  • Iron deficiency anemia prevalence was similar (6%) in both febrile seizure and control groups.
  • A significantly higher proportion (58%) of children with febrile seizures had an SI/TIBC ratio below 12% compared to controls (29%).

Conclusions:

  • While anemia was not a distinguishing factor, iron deficiency, indicated by a low SI/TIBC ratio, was more prevalent in children with febrile seizures.
  • This suggests a potential link between iron deficiency and febrile seizures in young children.
Abstract

Keywords:
AnemiaFebrileIron deficiencySeizures

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