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The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
Published on: January 13, 2022
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Barriers of the peripheral nerve
Sirkku Peltonen1, Maria Alanne2, Juha Peltonen2
1Department of Dermatology; Turku University Hospital and University of Turku; Turku, Finland.
Tissue Barriers
|March 26, 2014
Summary
This review details peripheral nerve anatomy and the molecular basis of its barrier functions. It explains how tight junctions maintain nerve homeostasis and discusses future therapies targeting these barriers.
Area of Science:
- Neuroscience
- Cell Biology
- Anatomy
Background:
- Peripheral nerves possess distinct anatomic compartments visualized through microscopy.
- Understanding nerve barrier functions is crucial for neurological health.
Purpose of the Study:
- To review the anatomic, cellular, and molecular basis of peripheral nerve barriers.
- To elucidate the in situ control of peripheral nerve homeostasis.
- To discuss the role of claudin-containing tight junctions and the timeline of barrier development.
Main Methods:
- Review of light and electron microscopic topography.
- Exploration of cellular and molecular mechanisms.
- Analysis of in situ homeostasis control.
- Depiction of the human timeline of barrier development.
Main Results:
- Peripheral nerves have defined compartments with specific barrier functions.
- Claudin-containing tight junctions are key components of these barriers.
- Nerve homeostasis is tightly regulated in situ.
- The development of these barriers follows a specific human timeline.
Conclusions:
- Peripheral nerve barriers are essential for maintaining nerve homeostasis.
- Claudin-based tight junctions play a critical role in barrier integrity.
- Future therapies may target these barriers for neurological conditions.
Keywords:
Schwann cellbasement membraneendothelial cellperineurial cellperineuriumperipheral nervetight junctiontranscytosisMore Related Videos
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