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Eribulin drug review

Nishitha Shetty1, Sudeep Gupta1

  • 1Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

South Asian Journal of Cancer
|March 26, 2014
PubMed

Insights

Eribulin mesylate is a life-saving anticancer drug derived from a marine sponge, effective for metastatic breast cancer resistant to other treatments. Ongoing trials explore its potential in various other refractory tumors.

Area of Science:

  • Oncology
  • Pharmacology
  • Marine Biotechnology

Background:

  • Eribulin mesylate is a synthetic macrocyclic ketone analog of halichondrin B, originally isolated from the marine sponge Halichondria okadai.
  • It is approved for patients with metastatic breast cancer who have progressed on anthracyclines and taxanes.
  • Eribulin functions as a microtubule dynamics inhibitor, leading to prolonged mitotic arrest and apoptosis.

Purpose of the Study:

  • To review the efficacy and safety of eribulin mesylate in metastatic breast cancer.
  • To discuss its mechanism of action and potential applications in other malignancies.

Main Methods:

  • Review of clinical trial data and scientific literature on eribulin mesylate.
  • Analysis of its pharmacokinetic and pharmacodynamic properties.
  • Evaluation of its role in various cancer types.

Main Results:

  • Eribulin demonstrates significant efficacy in heavily pre-treated metastatic breast cancer patients.
  • Common adverse events include neutropenia, neuropathy, and QT prolongation.
  • Phase I/II trials are investigating eribulin in lung, ovarian, pancreatic, bladder, and soft tissue tumors.

Conclusions:

  • Eribulin mesylate is a valuable therapeutic option for refractory metastatic breast cancer.
  • Its potential utility in a broader range of solid tumors is under active investigation.
  • Further prospective studies are crucial to establish its role in diverse oncological settings.
Keywords:
Eribulinbreast chemotherapytaxane

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