[Progress on suxamethonium chloride analysis]

Area of Science:

• Anesthesiology and Pharmacology
• Analytical Chemistry

Background:

• Suxamethonium chloride is a depolarizing neuromuscular blocking agent crucial in general anesthesia.
• Overdoses of suxamethonium chloride can lead to life-threatening cardiovascular events, including bradycardia, arrhythmia, and cardiac arrest.

Purpose of the Study:

• To review and summarize the progress in analytical testing methodologies for suxamethonium chloride.
• To provide an overview of various detection techniques relevant to suxamethonium chloride analysis.

Main Methods:

• Infrared spectroscopy
• Chemical colorimetric reactions
• Chemical titration
• Enzyme-based electrochemical sensors
• Chromatographic techniques (e.g., HPLC, GC)
• Mass spectrometry (MS)

Main Results:

• The article details the principles and applications of diverse analytical methods for suxamethonium chloride detection.
• Each method's advantages and limitations in sensitivity, specificity, and practicality are discussed.

Conclusions:

• Accurate and reliable testing methods are essential for managing suxamethonium chloride toxicity.
• Continued development in analytical techniques will improve the diagnosis and management of suxamethonium chloride-related adverse events.