Related Experiment Video

Updated: May 1, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

14.3K

[Ménétrieŕs disease associated with cytomegalovirus infection]

B Fernández Caamaño1, E Ramos Boluda1, E Martínez-Ojinaga Nodal1

  • 1Servicio de Gastroenterología, Hospital Universitario La Paz, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|March 27, 2014
PubMed

Insights

Menetrier disease in children is a rare, self-limited condition often caused by cytomegalovirus. Prompt diagnosis and treatment lead to a favorable prognosis and symptom resolution within weeks.

Area of Science:

  • Pediatric Gastroenterology
  • Viral Infections
  • Gastrointestinal Disorders

Background:

  • Menetrier disease is a rare condition in children characterized by protein-losing gastroenteropathy, gastric mucosal hypertrophy, and edema.
  • While often viral in adults, cytomegalovirus (CMV) is the most common cause in pediatric cases.
  • Unlike in adults, pediatric Menetrier disease typically follows a self-limited course with a good prognosis.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and outcomes of pediatric Menetrier disease.
  • To highlight the association with cytomegalovirus infection in children.
  • To emphasize the generally favorable prognosis in this pediatric population.

Main Methods:

  • Retrospective review of four pediatric patients diagnosed with Menetrier disease over five years.
  • Analysis of clinical symptoms, endoscopic findings, and diagnostic workup, including CMV testing.
  • Evaluation of treatment response and patient outcomes.

Main Results:

  • Four patients (3 boys, 1 girl) with a mean age of 28.7 months presented with fever, vomiting, and edema.
  • Endoscopic findings included thickened gastric folds and erosions.
  • All patients had concurrent gastric cytomegalovirus infection and experienced symptom resolution within weeks.

Conclusions:

  • Pediatric Menetrier disease, frequently linked to cytomegalovirus, presents with characteristic gastrointestinal symptoms and endoscopic findings.
  • The disorder is typically self-limiting in children, with a favorable prognosis and rapid recovery.
  • Early identification of CMV infection is crucial for managing pediatric Menetrier disease effectively.
Keywords:
CitomegalovirusCytomegalovirusEnfermedad de MénétrierGastroenteropatía pierde proteínasGastropatía hipertróficaHypertrophic gastropathyMénétrier diseaseProtein-losing gastroenteropathy

More Related Videos

Merkel Cell Polyomavirus Infection and Detection13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

9.6K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.4K

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
199
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
15
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
22
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805