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Autoimmune response in children with dengue. Case reports
1Servicio de Pediatría, Reumatología Pediátrica, Hospital Central del Instituto de Previsión Social, Asunción, Paraguay.
Reumatologia Clinica
|March 27, 2014
Summary
Dengue virus infection can trigger autoimmune responses, including macrophage activation syndrome. Physicians should consider dengue as a cause of unusual autoimmune conditions in endemic areas.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Dengue virus (DV) infection can lead to severe outcomes like dengue hemorrhagic fever and shock syndrome.
- DV infection is known to induce auto-antibody production against human cells.
- Macrophage activation syndrome (MAS) is associated with infections, drugs, and autoimmune diseases.
Observation:
- Three patient cases are presented with clinically evident autoimmune responses following dengue virus infection.
- The patients developed unusual conditions potentially linked to their dengue infection.
- The study highlights a possible connection between dengue and autoimmune pathologies.
Findings:
- Dengue virus infection can precipitate autoimmune responses in susceptible individuals.
- Autoimmune manifestations, including MAS, may occur secondary to dengue virus infection.
- Hyperimmune responses to dengue are prevalent in the region studied.
Implications:
- Dengue virus infection should be considered in the differential diagnosis of unexplained autoimmune conditions.
- Increased awareness among physicians is crucial for timely diagnosis and management of dengue-associated autoimmune syndromes.
- Further research is warranted to elucidate the mechanisms linking dengue virus infection to autoimmune pathogenesis.
Keywords:
Autoinmune responseDengueHemophagocytic syndromeMacrophage activation syndromeRespuesta autoinmuneSíndrome de activación de macrófagosSíndrome hemofagocíticoMore Related Videos
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