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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Tbl1xr1 Promotes Lymphangiogenesis And Lymphatic Metastasis In Esophageal Squamous Cell Carcinoma.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Tbl1xr1 Promotes Lymphangiogenesis And Lymphatic Metastasis In Esophageal Squamous Cell Carcinoma.

    • Related Experiment Videos

    TBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma.

    Liping Liu1, Chuyong Lin2, Weijiang Liang3

    • 1State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China Guangzhou Research Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.

    Gut
    |March 27, 2014

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) promotes esophageal squamous cell carcinoma (ESCC) lymphangiogenesis and metastasis by upregulating VEGF-C. TBL1XR1 is a potential prognostic biomarker and therapeutic target for ESCC patients.

    Related Experiment Videos

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) is involved in transcriptional regulation.
    • Its role in esophageal squamous cell carcinoma (ESCC) is not fully understood.

    Purpose of the Study:

    • To investigate the biological function and clinical significance of TBL1XR1 in ESCC.
    • To explore the underlying molecular mechanisms of TBL1XR1 action in ESCC.

    Main Methods:

    • TBL1XR1 expression was analyzed in ESCC cell lines and clinical tissues using immunoblotting and immunohistochemistry.
    • In vitro and in vivo assays were performed to assess TBL1XR1's role in lymphangiogenesis and metastasis.
    • Molecular mechanisms involving VEGF-C were investigated using real-time PCR, ELISA, luciferase reporter assays, and chromatin immunoprecipitation.

    Main Results:

    • TBL1XR1 expression was significantly upregulated in ESCC and correlated with advanced disease stage and poorer patient survival.
    • TBL1XR1 overexpression promoted lymphangiogenesis and lymphatic metastasis in ESCC, while silencing had the opposite effect.
    • TBL1XR1 was shown to induce VEGF-C expression by binding to the VEGF-C promoter, a correlation confirmed in clinical samples and other cancers.

    Conclusions:

    • TBL1XR1 induces lymphangiogenesis and lymphatic metastasis in ESCC through VEGF-C upregulation.
    • TBL1XR1 serves as a potential prognostic biomarker for ESCC.
    • TBL1XR1 represents a promising therapeutic target for ESCC treatment.