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Risk factors for congenital hydrocephalus: a nationwide, register-based, cohort study

Tina Noergaard Munch1, Marie-Louise Hee Rasmussen2, Jan Wohlfahrt2

  • 1Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.

Journal of Neurology, Neurosurgery, and Psychiatry
|March 27, 2014
PubMed

Insights

Firstborn infants have a higher risk of isolated congenital hydrocephalus (CHC). Maternal antidepressant use in early pregnancy also increases CHC risk, warranting further research into these associations.

Area of Science:

  • Pediatric Neurology
  • Obstetrics and Gynecology
  • Pharmacoepidemiology

Background:

  • Congenital hydrocephalus (CHC) is a complex condition with both isolated and syndromic forms.
  • Understanding risk factors for isolated CHC is crucial for early detection and intervention.

Purpose of the Study:

  • To investigate associations between isolated CHC and maternal/infant factors.
  • To identify risk factors unique to isolated CHC versus syndromic CHC.

Main Methods:

  • Nationwide, register-based cohort study of Danish births (1978-2008).
  • Utilized national registers for CHC, maternal diseases, medication use, and birth data.
  • Employed log-linear Poisson regression to estimate rate ratios for isolated and syndromic CHC.

Main Results:

  • Identified 1193 cases of isolated CHC in 1,928,666 live births.
  • Firstborns showed an increased risk of isolated CHC (RR 1.32).
  • First-trimester maternal antidepressant use significantly elevated isolated CHC risk (RR 2.52).
  • Male gender, multiples, and maternal diabetes were risk factors for syndromic CHC.

Conclusions:

  • Firstborn status and maternal antidepressant use are key risk factors for isolated CHC.
  • Further research is needed to explore the biological mechanisms linking antidepressants to CHC.
  • Behavioral aspects and comorbidities associated with maternal antidepressant use require investigation.
Abstract

Keywords:
CSFNEUROEPIDEMIOLOGYNEUROSURGERYPAEDIATRIC NEUROSURGERY

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