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Updated: May 1, 2026
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
Focus issue: Refining the war on cancer
1Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
Abstract:
Treating cancer involves not only stemming the growth of the primary tumor but also preventing its progression to metastatic disease. Advances in our understanding of the molecular pathways that transform healthy cells and maintain the proliferative advantage of tumor cells have enabled the development of targeted therapeutics, but preventing drug resistance and the switch to metastatic disease remains challenging. As this week's issue of Science Signaling highlights, dissection of the pathways that regulate inflammation in the tumor microenvironment and insight into the molecular changes that occur in cells in response to therapy may improve clinical strategies, particularly for aggressive breast and skin cancers.
Insights
Preventing cancer spread (metastasis) and drug resistance is key. Understanding tumor microenvironment inflammation and cellular responses to therapy can improve treatments for aggressive cancers.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Cancer treatment aims to inhibit primary tumor growth and prevent metastasis.
- Targeted therapeutics have emerged from understanding cancer cell molecular pathways.
- Drug resistance and metastatic progression remain significant clinical challenges.
Discussion:
- The tumor microenvironment's inflammatory pathways are crucial for cancer progression.
- Cellular responses to cancer therapies require detailed investigation.
- Understanding these processes can inform new therapeutic strategies.
Key Insights:
- Dissecting inflammation in the tumor microenvironment is vital.
- Analyzing molecular changes in cells during therapy is essential.
- These insights are particularly relevant for aggressive breast and skin cancers.
Outlook:
- Improved clinical strategies for aggressive cancers are anticipated.
- Further research into molecular pathways may yield novel treatments.
- Combating drug resistance and metastasis remains a primary goal.
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