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Platelet serotonin transporter function predicts default-mode network activity.

Christian Scharinger1, Ulrich Rabl1, Christian H Kasess2

  • 1Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

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Summary
This summary is machine-generated.

Platelet serotonin transporter (5-HTT) uptake velocity (Vmax) predicts default-mode network (DMN) suppression in healthy individuals. This suggests neuronal 5-HT reuptake plays a key role in regulating the DMN.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • The serotonin transporter (5-HTT), encoded by SLC6A4, regulates extracellular serotonin (5-HT).
  • A link between platelet and brain serotonin uptake has been proposed.
  • The predictive value of platelet 5-HT uptake for neural network activation remains unclear.

Purpose of the Study:

  • To investigate if platelet serotonin transporter (5-HTT) maximal uptake velocity (Vmax) predicts neural activation in human brain networks influenced by serotonin.
  • To explore the relationship between platelet Vmax and default-mode network (DMN) activity.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was conducted on 48 healthy subjects.
  • Maximal 5-HT uptake velocity (Vmax) was measured in blood platelets.
  • Mixed-effects multilevel analysis (MEMA) was used to assess relationships between whole-brain BOLD activity and platelet Vmax.

Main Results:

  • Increased platelet Vmax significantly predicted default-mode network (DMN) suppression.
  • This prediction was independent of genetic variations in SLC6A4.
  • Platelet Vmax correlated with global DMN activation, not intrinsic DMN connectivity.

Conclusions:

  • Platelet Vmax serves as a predictor of global DMN activation changes in healthy individuals.
  • These findings support the hypothesis of a platelet-synaptosome Vmax coupling.
  • Neuronal 5-HT reuptake appears crucial for regulating the DMN.