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Serum myeloid-related protein 8/14 complex is associated with microalbuminuria in patients with type 2 diabetes

Christoph Schmaderer1, Stephan Kemmner2, Klaus Burkhardt3

  • 1Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany christoph.schmaderer@lrz.tum.de.

Therapeutic Advances in Cardiovascular Disease
|March 27, 2014
PubMed
Abstract

Insights

Microalbuminuria (MA) in type 2 diabetes patients is linked to higher levels of myeloid-related protein 8/14 (MRP8/14), indicating macrophage activation. This suggests inflammation plays a role in the increased cardiovascular risk associated with MA.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Microalbuminuria (MA) is an independent predictor of cardiovascular risk and renal disease progression in diabetic patients.
  • MA is linked to microvascular defects and inflammation, with activated macrophages playing a key role.
  • Myeloid-related protein 8/14 complex (MRP8/14) is secreted by transmigrating macrophages.

Purpose of the Study:

  • To investigate the association between microalbuminuria (MA) and elevated myeloid-related protein 8/14 (MRP8/14) levels in patients with type 2 diabetes.
  • To determine if MA predicts MRP8/14 levels, suggesting macrophage activation in diabetic cardiovascular risk.

Main Methods:

  • 86 men with type 2 diabetes were categorized into normoalbuminuria and MA groups.
  • Serum MRP8/14 levels were quantified using enzyme-linked immunosorbent assay.
  • Cardiovascular risk factors were assessed and compared between groups.

Main Results:

  • Albuminuria showed a positive correlation with MRP8/14 levels (r = 0.34) and systolic blood pressure (r = 0.33).
  • Patients with MA had significantly higher MRP8/14 levels compared to those with normoalbuminuria.
  • MA independently predicted higher MRP8/14 levels, systolic blood pressure, and hemoglobin A1c.

Conclusions:

  • Albumin excretion is associated with macrophage activation, as indicated by MRP8/14 levels.
  • These findings suggest tissue inflammation and macrophage activation contribute to elevated cardiovascular risk in type 2 diabetes.
Keywords:
calprotectindiabetes mellitus type 2macrophagesmicroalbuminuriamyeloid-related protein 8/14 complex

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