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Endocrine crosstalk between muscle and bone.

Marco Brotto1, Mark L Johnson

  • 1Muscle Biology Research Group-MUBIG, UMKC School of Nursing & Health Studies and School of Medicine, 2464 Charlotte Street, Kansas City, MO, 64108, USA, brottom@umkc.edu.

Current Osteoporosis Reports
|March 27, 2014
PubMed
Summary

Muscles and bones, beyond mechanical roles, communicate biochemically. This crosstalk is vital for musculoskeletal health and function, opening new research avenues.

Area of Science:

  • Biochemistry
  • Physiology
  • Anatomy

Background:

  • The musculoskeletal system, crucial for locomotion, involves bones, muscles, and connective tissues.
  • Historically, mechanical interactions dominated musculoskeletal research.
  • Emerging evidence highlights biochemical crosstalk between muscles and bones.

Purpose of the Study:

  • To review novel concepts of biochemical interactions in the musculoskeletal system.
  • To present muscles and bones as secretory/endocrine organs.
  • To explore mutual genetic and tissue interactions and their implications.

Main Methods:

  • Review of current literature on musculoskeletal biochemical signaling.
  • Analysis of evidence for genetic and tissue interactions.

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  • Examination of pathophysiological examples of crosstalk.

    • Main Results:

    • Muscles and bones engage in significant biochemical signaling.
    • These interactions influence the function of both tissues.
    • Crosstalk mechanisms are critical for musculoskeletal health.

    Conclusions:

    • Muscles and bones act as endocrine organs, influencing each other.
    • Biochemical coupling is as important as mechanical coupling.
    • Understanding this crosstalk offers new therapeutic targets for musculoskeletal disorders.