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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Recent trends in drug delivery system using protein nanoparticles.
S Sripriyalakshmi1, Pinkybel Jose, Aswathy Ravindran
1Center for Nanotechnology and Advanced Biomaterials (CeNTAB), School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, Tamilnadu, India.
Cell Biochemistry and Biophysics
|March 27, 2014
Summary
Protein nanoparticles offer a promising solution for targeted drug delivery, improving therapeutic efficacy and reducing side effects. This review explores advancements in engineered nanoparticles for next-generation drug delivery systems.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Engineered nanoparticles are researched for drug formulation and passive tumor targeting.
- Current strategies often involve high drug dosages due to non-selective delivery.
- Carrier systems themselves can pose risks, highlighting the need for safer alternatives.
Purpose of the Study:
- To review recent progress in particle-based therapeutic delivery.
- To discuss key concepts in particle design for drug delivery.
- To explore biological barriers impacting nanoparticle-based drug delivery.
Main Methods:
- Literature review of engineered nanoparticles in drug delivery.
- Analysis of protein nanoparticles as drug carriers.
- Discussion of particle design principles and biological barriers.
Main Results:
- Protein nanoparticles are biocompatible, biodegradable, and modifiable for drug binding, imaging, and targeting.
- Nanocarrier-based strategies enhance selective drug delivery to the site of action.
- Advancements in particle design are crucial for next-generation drug delivery systems.
Conclusions:
- Protein nanoparticles show significant potential as drug carriers.
- Optimized particle design and understanding biological barriers are essential for effective drug delivery.
- Future research should focus on developing advanced, safe, and targeted nanoparticle systems.
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