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Related Experiment Video

Updated: May 1, 2026

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Trabeculotomy ab interno with internal limiting membrane forceps for open-angle glaucoma.

Houmei Nakasato1, Riyo Uemoto, Masaru Isozaki

  • 1Department of Ophthalmology, Odawara Municipal Hospital, Odawara, Japan.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|March 27, 2014
PubMed
Summary

This study introduces a new technique for trabeculotomy ab interno in open-angle glaucoma (OAG) patients. The procedure effectively reduced intraocular pressure and medication needs, with minor complications observed.

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Area of Science:

  • Ophthalmology
  • Surgical Innovation

Background:

  • Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
  • Current treatments aim to lower intraocular pressure (IOP) but can have limitations.

Purpose of the Study:

  • To describe a novel technique for performing trabeculotomy ab interno.
  • To evaluate the efficacy and safety of this new surgical approach for OAG.

Main Methods:

  • A retrospective study involving 26 eyes of 23 patients with OAG.
  • A 25-gauge forceps was used to strip the inner wall of Schlemm's canal for 100°-120°.
  • Intraocular pressure (IOP) and medication use were recorded pre- and post-surgery up to 33 months.

Main Results:

  • Significant IOP reduction (P<0.05) observed at multiple time points post-surgery.
  • Significant reduction in glaucoma medication use (P<0.001) was noted.
  • No vision-threatening complications occurred; 92.3% experienced postoperative anterior chamber blood clots.

Conclusions:

  • Trabeculotomy ab interno using this technique is effective for OAG.
  • Minor complications like blood clots are common, but serious complications were avoided.
  • Further studies with larger cohorts and longer follow-up are warranted to confirm long-term effectiveness.