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Outcome of a repair-oriented strategy for the aortic valve in children
Pramod Kandakure1, Natasha Prior, Giri Soda
1Cardiac Surgical Unit, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.
Insights
Aortic valve repair in children shows good mid-term outcomes, offering a promising surgical option for pediatric aortic valve disease. This strategy effectively reduced stenosis gradients and improved regurgitation, with high freedom from reintervention.
Area of Science:
- Pediatric Cardiology
- Cardiac Surgery
- Congenital Heart Disease
Background:
- Aortic valve disease in children often requires surgical intervention.
- Evaluating repair-oriented strategies is crucial for long-term pediatric cardiac health.
- Understanding mid-term outcomes informs clinical decision-making for aortic valve disease in pediatric populations.
Purpose of the Study:
- To assess the mid-term results of a repair-focused approach for aortic valve issues in children.
- To determine the efficacy and safety of aortic valve repair in pediatric patients.
- To evaluate the impact of repair on aortic stenosis and regurgitation in children.
Main Methods:
- A cohort of 39 children underwent aortic valve repair between 2007 and 2011.
- Median patient age was 5.5 years, with a median follow-up of 12.7 months.
- Data collected included pre- and post-operative gradients, regurgitation severity, and reintervention rates.
Main Results:
- Early mortality was 7.7%, primarily in complex cases; 5.1% required early revision.
- Aortic stenosis gradient significantly decreased post-repair (P=.02) and remained stable.
- Aortic regurgitation improved in all moderate/severe cases (P=.04), with 95% freedom from reintervention at 3 years.
Conclusions:
- A repair-oriented strategy for pediatric aortic valve disease yields satisfactory early and mid-term results.
- This approach is a viable and promising management option for children with aortic valve conditions.
- Successful repair can significantly improve hemodynamic function and reduce the need for future interventions.
Background:
We sought to evaluate the mid-term results of a repair-oriented strategy of the aortic valve in children.
Methods:
Between February 2007 and November 2011, we performed 39 aortic valve repairs in children. Median age and weight at surgery were 5.5 years (3 days-18 years) and 16.7 kg (2.7-83.5), respectively. A total of 11 (28%) patients had one or more prior surgical or interventional cardiologic procedures. Median intensive care unit and hospital stay were two (1-96) and five (3-96) days, respectively. Median and cumulative follow-up were 12.7 months (15 days-64 months) and 48.9 patient-years, respectively.
Results:
There were 3 (7.7%) early deaths all in patients undergoing additional complex cardiac procedures. Two (5.1%) patients required early surgical revision. Twenty-six (66%) patients had isolated or mixed aortic stenosis. The median gradient reduced from 62.4 (range 16-144) to 17.6 mm Hg (range 0-51.8), postoperatively (P = .02). At last follow-up, the median gradient remained largely unchanged at 21.1 mm Hg (0-49; P = .02). Twenty-six (66%) patients had isolated or mixed aortic valve regurgitation (mild in 8 [20%], moderate in 15 [38%], and severe in 6 ([15%] patients). The degree of aortic regurgitation improved in all patients with moderate or severe aortic regurgitation (P = .04). At last follow-up, two patients had moderate aortic regurgitation. Kaplan Meier freedom from reintervention in the survivors was 95% at three years.
Conclusions:
A repair-oriented strategy for the aortic valve in children has satisfactory early and mid-term results and remains a promising management option in children with aortic valve disease.
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