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Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

Hendra Salim1, I Putu Gede Karyana, I Gusti Ngurah Sanjaya-Putra

  • 1Division of Gastroenterology and Hepatology, Department of Child Health, Medical School, Udayana University/Sanglah Hospital, Denpasar, Indonesia. misionarispelayanan@yahoo.com.

BMC Gastroenterology
|March 28, 2014
PubMed

Insights

Rotavirus is a leading cause of severe diarrhea in hospitalized children. Boys are at higher risk, while good nutrition and breastfeeding offer protection against rotavirus diarrhea.

Area of Science:

  • Pediatric infectious diseases
  • Public health surveillance
  • Gastroenterology

Background:

  • Diarrhea is a significant global health issue, particularly for children under five.
  • Rotavirus is a primary cause of pediatric hospitalization and mortality due to diarrhea.
  • Limited data exists on rotavirus diarrhea risk factors and burden in Indonesia.

Purpose of the Study:

  • To investigate risk factors, disease burden, and mortality associated with rotavirus diarrhea.
  • To analyze rotavirus diarrhea in hospitalized children at Sanglah Hospital, Denpasar.

Main Methods:

  • A prospective cohort study was conducted from April 2009 to December 2011.
  • Inclusion criteria: children under 5 years hospitalized with acute diarrhea.
  • Stool samples analyzed for rotavirus antigen using immunoassay.

Main Results:

  • Diarrhea prevalence was 11.3% among 5805 hospitalized children.
  • Rotavirus diarrhea prevalence was 49.8% among pediatric diarrhea cases.
  • Vomiting was significantly more frequent in rotavirus diarrhea cases (RR 1.4).

Conclusions:

  • Rotavirus is the predominant cause of pediatric diarrhea hospitalizations.
  • Male children face a higher risk of rotavirus infection compared to females.
  • Breastfeeding and good nutritional status provide protection against rotavirus and non-rotavirus diarrhea.
Abstract

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