Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

13.3K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
13.3K
Micelles01:30

Micelles

364
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
364
BIBO stability of continuous and discrete -time systems01:24

BIBO stability of continuous and discrete -time systems

1.1K
System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system....
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implicit membrane for helical peptide selectivity toward bacterial membranes.

Biophysical journal·2026
Same author

Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Correction to "Martini 3 Limitations in Phospholipid Flip-Flop".

Journal of chemical theory and computation·2026
Same author

The second Gibbs paradox.

The Journal of chemical physics·2026
Same author

Monte Carlo methods, 70 years after "Equation of state calculations by fast computing machines" by Nicholas Metropolis, Arianna Rosenbluth, Marshall Rosenbluth, Augusta Teller, and Edward Teller (1953).

The Journal of chemical physics·2025
Same author

Helical sensors of membrane saturation: Changes in orientation and curvature preference.

Biophysical journal·2025
Same journal

Immobilization of Ytterbium via Polyphenol Chemistry on Implant Materials for Enhanced Cytocompatibility and Antibacterial Properties.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Electrochemical Oxidation Strategy for Integrated CO<sub>2</sub> Capture and Conversion.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Probing Molecular Structural Changes of Buried Interfaces between Polyethylene and Nylon in Polymer Thin Films after Stretching.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Charge Dependence of Local Hydration Dynamics in Poly(Acrylic Acid) Solutions.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Amphiphilic Lubricants Linked by Hydrogen Bonds Achieve Superlubricity and Enhance Water/Oil Tribological Properties.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Spin Dewetting of Ultrathin Polymer Films.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method
07:26

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method

Published on: January 9, 2012

23.1K

Stability of bicelles: a simulation study.

Robert Vácha1, Daan Frenkel

  • 1National Centre for Biomolecular Research, Faculty of Science and CEITEC - Central European Institute of Technology, Masaryk University , Kamenice 5, 625 00 Brno-Bohunice, Czech Republic.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 28, 2014
PubMed
Summary
This summary is machine-generated.

This study used simulations to investigate bicelle stability, finding they destabilize at higher temperatures. Uncharged lipid mixtures showed no stable bicelles, suggesting charge or dopants may be necessary.

More Related Videos

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
06:47

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

Published on: August 25, 2023

1.9K
Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

6.9K

Related Experiment Videos

Last Updated: May 1, 2026

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method
07:26

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method

Published on: January 9, 2012

23.1K
Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
06:47

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

Published on: August 25, 2023

1.9K
Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
09:38

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

6.9K

Area of Science:

  • Biophysics
  • Computational Chemistry
  • Materials Science

Background:

  • Bicelles, disk-like aggregates of lipids and detergents, are crucial for membrane protein studies.
  • Understanding the thermodynamic stability of bicelles is essential for their application in NMR and protein crystallization.
  • Current knowledge on factors influencing bicelle formation and stability is limited.

Purpose of the Study:

  • To investigate the relationship between lipid-aggregate morphology and surfactant mixture composition and temperature.
  • To explore the thermodynamic stability of bicelles using coarse-grained simulations.
  • To identify parameters governing bicelle formation and stability.

Main Methods:

  • Coarse-grained molecular dynamics simulations.
  • Analysis of lipid-aggregate morphology under varying temperature and composition.
  • Thermodynamic stability assessment of bicelles versus other phases.

Main Results:

  • Bicelles destabilize at higher temperatures, with detergents favoring membrane edges.
  • The free-energy difference between bicelles and perforated lamellar phases is minimal for non-curved, uncharged molecules.
  • No thermodynamically stable bicelles were observed in studied uncharged lipid mixtures.

Conclusions:

  • Bicelle stability is sensitive to temperature and composition.
  • The formation of thermodynamically stable bicelles may require specific molecular properties like charge or dopants.
  • Further research into charged or doped systems is warranted to achieve stable bicelles.