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Updated: May 1, 2026
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
[Donations after cardiac death kidney transplantation in northwest China]
Xiaoming Pan1, Wujun Xue, Linjuan Liu
1Nephropathy Center, the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, shannxi, China.
Insights
Donations after cardiac death (DCD) kidney transplants show good outcomes, though delayed graft function (DGF) is common. Low-temperature mechanical perfusion reduces DGF incidence, improving kidney transplant success rates.
Area of Science:
- Nephrology
- Transplantation immunology
- Organ procurement
Context:
- Donations after cardiac death (DCD) kidney transplantation is a growing area in organ donation.
- Northwest China faces challenges in managing DCD kidney transplants and delayed graft function (DGF).
Purpose:
- To evaluate the outcomes of DCD kidney transplants in Northwest China.
- To identify effective management strategies for DGF following DCD kidney transplantation.
Summary:
- A study of 94 DCD kidney transplants revealed a 29.3% success rate and a 27.7% incidence of DGF.
- While early graft function differed, long-term survival rates were comparable between DGF and non-DGF groups.
- LifePort mechanical perfusion significantly reduced DGF compared to simple cold preservation (21.5% vs. 41.4%).
Impact:
- DCD kidney transplantation offers a viable option for increasing kidney availability.
- Implementing low-temperature mechanical perfusion can mitigate DGF and improve transplant outcomes.
- This research provides valuable data for optimizing DCD kidney transplant protocols in the region.
Objective:
To explore the effect of donations after cardiac death (DCD) kidney transplant performed in northwest China and the measures for management of delayed graft function (DGF).
Methods:
In the period of 2011-2013, a total of 51 families of DCD donor gave their consent to organ donation by signing the informed consent with the help by a Red Cross Organization (ROC) coordinator, and 102 kidneys were retrieved by organ procurement organization (OPO) teams. Ninety-four operations of renal transplantation were carried out in our hospital. All the patients were followed-up and based on the occurrence of DGF after transplantation, they were divided into DGF group and non-DGF group for comparative studies.
Results:
The success rate of donation after cardiac death was 29.3%, and the incidence of post-transplantation DGF was 27.7%. The 1-year human/kidney survival rate was 98.9%/95.7%. Within six months after the transplant, the values of eGFR in DGF group were significantly lower and serum creatinine significantly higher than those in non-DGF group (P<0.05), but no significant differences were found between the two groups thereafter (P>0.05). The occurrence of DGF in LifePort mechanical perfusion cohorts was significantly lower than that in the simple cold preservation group (21.5% vs. 41.4%, P<0.05).
Conclusion:
The overall effect of DCD kidney transplant is good despite a high incidence of early DGF, and we recommend the use of low-temperature mechanical perfusion for storage and transportation of DCD donor kidney.
Related Concept Videos
01:28Kidney Transplant I: Introduction
01:26Kidney Transplant II: Surgical Procedure
01:16Kidney Transplant III: Nursing Management