Related Experiment Video
Updated: May 1, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Utilization of rapid infusion system with cold saline in the induction of therapeutic hypothermia
Sung Woong Jin1, Yoon Hee Choi2, Dong Hoon Lee3
1Department of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Objective:
To examine the cooling effectiveness of a rapid infusion system (RIS) during induction of therapeutic hypothermia.
Methods:
This laboratory study simulated the effect of three fluid delivery methods: rapid dripping without any other equipment (control); RIS; pressure bag. Cold energy loss (℃ × min) was calculated as: (temperature of the proximal thermoprobe--temperature of the distal thermoprobe) × (total infusion time).
Results:
Infusion time was significantly shorter and cold energy loss significantly lower in the RIS group than in the two other groups.
Conclusions:
RIS preserves the cold energy of fluid more effectively than pressure bag or control. RIS allows for rapid infusion at a constant pressure and can be easily applied in an emergency setting.
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