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Comment on "drug discovery: turning the titanic"
W Joost Lesterhuis1, Anthony Bosco, Richard A Lake
1School of Medicine and Pharmacology and National Centre for Asbestos Related Diseases, University of Western Australia, Harry Perkins Institute of Medical Research, 5th Floor, QQ Block, 6 Verdun Street, Nedlands, Perth, Western Australia 6009, Australia.
Science Translational Medicine
|March 28, 2014
Summary
Focusing on resolving disease mechanisms, not just evolving ones, can uncover novel drug targets. This pathobiology-based research offers new avenues for drug discovery and development.
Area of Science:
- Biomedical Research
- Drug Discovery
- Pathobiology
Background:
- The dominant paradigm in drug discovery relies on understanding disease pathobiology.
- Decades of research have focused on evolving disease mechanisms.
Discussion:
- This research proposes a shift in focus towards the molecular and cellular events governing disease resolution.
- Investigating how diseases resolve may uncover previously unrecognized therapeutic targets.
Key Insights:
- Identifying pathways involved in disease resolution offers a novel strategy for drug discovery.
- This approach complements traditional methods by exploring the 'other side' of disease progression.
Outlook:
- This novel perspective could lead to the identification of new druggable pathways.
- Future research will explore the molecular underpinnings of disease resolution for therapeutic development.
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